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M94A3128.TXT
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1994-10-25
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Document 3128
DOCN M94A3128
TI Pathogeny recapitulates epidemogeny.
DT 9412
AU Pieczenik G; Cook College, Rutgers University, New Brunswick, N.J.
08903.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):147 (abstract no. PB0014). Unique
Identifier : AIDSLINE ICA10/94369447
AB I wish to propose that the course of the pathology of a disease in an
individual, pathogeny, can recapitulate the fluctuations in virulence in
a population during the course of an epidemic, epidemogeny. One model
for the fluctuation in virulence in a population during the course of an
epidemic is that of a non or less pathogenic strain competing out a more
pathogenic strain. This may be the evolution of the AIDS epidemic. This
model predicts a high degree of infectious virulence, followed by
clusters of infectious hypovirulence, followed by an attenuation of the
symptoms of the disease, followed by a termination of the epidemic.
Pathogeny recapitulating epidemogeny suggests that in an individual
infected with a pathogenic strain of HIV-1 can become infected, post
exposure, to a competitive non-pathogenic strain of HIV-1. This would
lead to a concomitant attenuation of clinical symptoms; followed by an
HIV-1 positive asymptomatic status; followed by a seroconversion to an
asymptomatic HIV-1 negative status. One can, therefore, expect that the
AIDS epidemic will follow the natural course of epidemics and evolve a
less pathogenic, avirulent, but more competitive strains of HIV-1. This
non-pathogenic competitive strain should limit the severity and spread
of the AIDS epidemic in time. I have recently identified a recombinant
HIV-1 strain isolated from a healthy long term asymptomatic American,
who showed infectious hypovirulence, (1) and which contains sections of
an avirulent African strain. This suggests that such a virus has
recently evolved and is entering the population at large. Because of the
Africans strain's nucleotide homology to Western strains, it was able to
recombine with the more pathogenic Western strain. However, this
recombinant retained the avirulence phenotype of the African strain. The
region of recombination between these two strains, therefore, identifies
more precisely, the nucleotide sequence responsible for the clinical
phenotype of pathogenicity; or, in this case, the clinical phenotype of
being a long term asymptomatic. In summary, a pathogenic African strain
is competed out by a less pathogenic African strain which enters the
American population as an avirulent competitive recombinant, which in
turn should compete out the more pathogenic strains in America, limiting
the course of the epidemic. Individuals infected with this
non-pathogenic strain, post-exposure to a pathogenic strain, show an
amelioration of symptoms and viral conversion to the non-pathogenic
strain. This recapitulates the course of the epidemic which, also, shows
a conversion from more virulence to less virulence.
DE Acquired Immunodeficiency Syndrome/*EPIDEMIOLOGY/*PHYSIOPATHOLOGY
Africa Human HIV-1/GENETICS/ISOLATION & PURIF/*PATHOGENICITY Models,
Theoretical Recombination, Genetic Species Specificity United
States/EPIDEMIOLOGY Virulence MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).